Intros Cannabis and immune system

[Bobster16]

This might sound odd…but is there any link between MC and lowered immune system ? I’m not seeming to get going with the oils because I start and a few days in I come down with a stinking cold. I wait for it to go away and start again - couple of days and I’m ill again. Due to my medical conditions, if I get a cold I tend to take a while to get over it compared to when I was younger.
I’m hooing it’s a resounding ‘no’ but is there any link between the two?

 

[Dooby Doo]

This might sound odd…but is there any link between MC and lowered immune system ? I’m not seeming to get going with the oils because I start and a few days in I come down with a stinking cold. I wait for it to go away and start again - couple of days and I’m ill again. Due to my medical conditions, if I get a cold I tend to take a while to get over it compared to when I was younger.
I’m hooing it’s a resounding ‘no’ but is there any link between the two?

I haven't heard any negatives from people who haven't any immune system. When you take oil you don't feel the effects as you would vaping/smoking and having a cold can sometimes feel like Cannabis isn't working for you, not all the time.

 

[Bobster16]

Thanks
I did notice that I couldn’t feel much impact of the cannabis when I’ve got cold. My worry was that it was the MC that is making me more susceptible to whatever bugs are going round.
Fingers crossed that it is just an unlucky coincidence

 

[GreenRed]

I am toking for 20+ years and have a pretty good immune system. Only started to break down a bit when the kid started going to school and she started bringing home the biological weapons they call "viruses", but then I caught up and that hits EVERYONE, don't need to be a patient for that.

 

[Bobster16]

I am toking for 20+ years and have a pretty good immune system. Only started to break down a bit when the kid started going to school and she started bringing home the biological weapons they call "viruses", but then I caught up and that hits EVERYONE, don't need to be a patient for that.

Good to hear

 

[Delta 9]

This might sound odd…but is there any link between MC and lowered immune system ? I’m not seeming to get going with the oils because I start and a few days in I come down with a stinking cold. I wait for it to go away and start again - couple of days and I’m ill again. Due to my medical conditions, if I get a cold I tend to take a while to get over it compared to when I was younger.
I’m hooing it’s a resounding ‘no’ but is there any link between the two?

Yes cannabis can be considered immunosuppressant and modulates immune system. Sounds like maybe cb2 activation with THC but just a guess. What was strength of oil any CBD there?
it may be that you had an infection and THC suppressed immune. It can happen but over 30 years on it and can count in maybe even 1 hand how many viral infections i have had but mainly CB1 Medical receptor activation delta 9.

 

[OldBloke]

Yes cannabis can be considered immunosuppressant and modulates immune system. Sounds like maybe cb2 activation with THC but just a guess. What was strength of oil any CBD there?
it may be that you had an infection and THC suppressed immune. It can happen but over 30 years on it and can count in maybe even 1 hand how many viral infections i have had but mainly CB1 Medical activation delta 9.

100%, for me high doses of cannabanoids etc are very useful. I have covid initiated MCAS ( amongst many other results!), simply put my immune system is triggered in error, it malfunctions and attacks processes and pathways it shouldn't... apparently including itself. Some research shows disruption to the Kreb Cycle too. 8-0

I used to avoid using cannabis before midday, a life long habit. These days I avoid wake and vape but I do start earlier, resulting in a slow but steady reduction in PEM duration and improving cfs severity.

That could be a result of inflamation reduction, but I'm beginning to think its immune system modulation by THC and all.

 

[Bobster16]

Yes cannabis can be considered immunosuppressant and modulates immune system. Sounds like maybe cb2 activation with THC but just a guess. What was strength of oil any CBD there?
it may be that you had an infection and THC suppressed immune. It can happen but over 30 years on it and can count in maybe even 1 hand how many viral infections i have had but mainly CB1 Medical receptor activation delta 9.

Thank you
I’ve tried 3 types so far….the original 10:10, then I tried a high CBD version - I didn’t feel any effect at all on this one. I am currently using 20:20.
The 20:20 seems to suit me best. I will continue with the 20:20 for now and see what happens.

 

[Delta 9]

Overactive immune system cannabis being an immunosuppressant will help calm it but underactive then i think it could it could make it worse.
MC they are more concerned with concerned irradiation as regards to immunocompromised patients than oil. It could be CBD cb2 issue but id stick with 20/20 see how it goes.

New post automatically merged: 8th Feb, 2026

100%, for me high doses of cannabanoids etc are very useful. I have covid initiated MCAS ( amongst many other results!), simply put my immune system is triggered in error, it malfunctions and attacks processes and pathways it shouldn't... apparently including itself. Some research shows disruption to the Kreb Cycle too. 8-0

I used to avoid using cannabis before midday, a life long habit. These days I avoid wake and vape but I do start earlier, resulting in a slow but steady reduction in PEM duration and improving cfs severity.

That could be a result of inflamation reduction, but I'm beginning to think its immune system modulation by THC and all.

So your immune system would be regarded as overactive then?

 

[OldBloke]

Overactive immune system cannabis being an immunosuppressant will help calm it but underactive then i think it could it could make it worse.
MC they are more concerned with concerned irradiation as regards to immunocompromised patients than oil. It could be CBD cb2 issue but id stick with 20/20 see how it goes.

New post automatically merged: 8th Feb, 2026

So your immune system would be regarded as overactive then?

Exactly that. Random in timing and level, unpredictable. You have a very deep understanding, for which thanks Are you a biochemist of some sort?

 

[Delta 9]

Exactly that. Random in timing and level, unpredictable. You have a very deep understanding, for which thanks Are you a biochemist of some sort?

This is where cannabis will act as an immunosuppressant to calm it , Do you resonate more with Caryophyllene terp in canna , jst a wonder cos of affinity for cb2 that might help. No lol i just love cannabis n love looking into it all when i have the energy

 

[OldBloke]

This is where cannabis will act as an immunosuppressant to calm it , Do you resonate more with Caryophyllene terp in canna , jst a wonder cos of affinity for cb2 that might help. No lol i just love cannabis n love looking into it all when i have the energy

Yes and Myrcene. A good GMO cultivar will put me to sleep for example. I love the Botany and the chemistry of the plant, like you I work with an energy deficit and most of my study these days goes in and is auto deleted, ageing brain Good to meet you.

 

[Delta 9]

Yes and Myrcene. A good GMO cultivar will put me to sleep for example. I love the Botany and the chemistry of the plant, like you I work with an energy deficit and most of my study these days goes in and is auto deleted, ageing brain Good to meet you.

Thought it would resonate, thats 2 of the best terpenes and activating/modulating the cb2 will b great for repair. Good on you for nailing down what works as it can be hard to get the right strains. I dont have the same enthusiasm as i once did but still there with alot less energy and for me its hard to keep knowledge in head with epilepsy and migraine with age lol , Likewise Old Bloke